saddle with A. 使某人承担苦差事 B. 以...为基础 C. 被..取代.
"A saddle with" 在英语中通常意味着让某人承担某种责任或苦差事。所以正确答案是:
A. 使某人承担苦差事
例如,"She was saddled with all the extra work after her colleague left."(她被迫承担了所有额外的工作,因为同事离开了。)